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GABA B Receptor 2 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112464-100µl
$279.00Price

Fig1: Western blot analysis of GABA B Receptor 2 on mouse cerebellum tissue lysate using anti- GABA B Receptor 2 antibody at 1/500 dilution.

Fig2: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti- GABA B Receptor 2 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue using anti- GABA B Receptor 2 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA112464
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB,IHC,FC,ICC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Gamma-aminobutyric acid type B receptor subunit 2, G-protein coupled receptor 51
  • Background

    In the central nervous system (CNS), gamma-aminobutyric acid (GABA) is the main main inhibitory neurotransmitter that functions to regulate neuronal firing. GABA exerts its effects through two different kinds of receptors: ionotropic receptors (GABAA R and GABAC R), which produce fast inhibitory signals, and metabotropic receptors (GABAB R), which produce slow inhibitory signals. The GABAB R receptor is a heterodimer that consists of two multi-pass membrane proteins, designated GABAB R1 and GABAB R2, both of which belong to the G protein-coupled receptor family and are highly expressed in brain tissue. Together, GABAB R1 and GABAB R2 play a crucial role in the fine-tuning of inhibitory synaptic transmissions and are implicated in slow wave sleep, muscle relaxation, hippocampal long-term potentiation and antinociception events. Both GABAB R1 and GABAB R2 are regulated by G proteins that have a variety of functions, including activation of potassium channels, inhibition of adenylyl cyclase (A cyclase) activity and modulation of inositol phospholipid hydrolysis.(ET7106-88)