Fusion glycoprotein F0 Rabbit polyclonal Antibody IgG

SKU: BA111197-100µl

Fig1: Western blot analysis of Fusion glycoprotein F0 on Fusion glycoprotein F0 transfected HEK293 cell lysates using anti- Fusion glycoprotein F0 antibody at 1/500 dilution.



Bon Opus Cat. #BA111197
  • Host Species; Species Reactivity

    Rabbit; Avian avulavirus 1
  • Immunogen

    Synthetic Peptide corresponding to Avian avulavirus 1 Fusion glycoprotein F0 aa 540-554.
  • Application Summary

  • Purification; Formulation

    Peptide affinity purified.; 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Fusion glycoprotein F0
  • Background

    During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participate in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.(ER1803-51)

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