Furin Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112510-100µl
$279.00Price

Fig1: Western blot analysis of Furin on different cell lysates using anti-Furin antibody at 1/500 dilution.

 Positive control:

 Lane 1: HepG2

      Lane 2: Hela

 Lane 3: Hela  

     Lane 4: MCF-7

 

Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Furin antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-Furin antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA112510
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein within human Furin aa 200-400
  • Application Summary

    WB,IHC,ICC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Furin, Dibasic-processing enzyme, Paired basic amino acid residue-cleaving enzyme
  • Background

    Furin (FUR, PACE, PCSK3, SPC1, Kex2p) is a calcium-dependent serine endoprotease that belongs to the subtilisin-like proprotein convertase family. The members of this family process latent precursor proteins into their biologically active products. Furin cleaves at paired basic amino acid processing sites within proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. Furin can directly cleave proMMP-2 within the trans-Golgi network leading to an inactive form of matrix metalloproteinase-2 (MMP-2). Furin is synthesized as an inactive zymogen that may minimize the occurrence of premature enzymatic activity that would lead to alternative protein activation or degradation. The inhibitory mechanism is based on the presence of an inactivating prosegment at the NH2 terminal of the Furin. After initial autocatalytic cleavage, the prosegment remains tightly associated until it reaches the trans-Golgi network where the dissociation of the prosegment and activation of furin occurs.(ET7107-37)

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