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©2019 by Bon Opus Biosciences, LLC.

FBXL2 Rabbit polyclonal Antibody IgG

SKU: BA110847-100µl
$279.00Price

Fig1: Western blot analysis of FBXL2 on different lysates using anti-FBXL2 antibody at 1/1,000 dilution.

 Positive control:

 Lane 1: Mouse liver tissue    Lane 2: Mouse heart tissue Lane 3: SiHa

Fig2: Western blot analysis of FBXL2 on rat liver tissue lysate using anti-FBXL2 antibody at 1/10,000 dilution.

Fig3: ICC staining FBXL2 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Bon Opus Cat. #BA110847
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, ICC, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    F-box/LRR-repeat protein 2, F-box and leucine-rich repeat protein 2, F-box protein FBL2/FBL3
  • Background

    Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication.(R1706-15)