FAM3A Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of FAM3A on recombinant protein using anti-FAM3A antibody at 1/1000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-FAM3A antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human fetal skeletal muscle tissue using anti-FAM3A antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityMouse; Human, Mouse, Rat
Application SummaryWB, IHC, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesProtein FAM3A, Cytokine-like protein 2-19
BackgroundThe FAM3 gene family is a novel cytokine-like gene family, which includes four members designated as FAM3A, FAM3B, FAM3C, and FAM3D. FAM3A is a secreted protein belonging to the FAM3 family of four alpha -helix bundle cytokines. It is expressed in multiple tissues. Mature human FAM3A shares approximately 93% amino acid sequence identity with the mouse and rat protein.FAM3A belongs to a novel cytokine-like gene family, and its physiological role remains largely unknown. FAM3A activated Akt through the p110α catalytic subunit of PI3K in an insulin-independent manner. Blockade of P2 ATP receptors or downstream phospholipase C (PLC) and IP3R and removal of medium calcium all significantly reduced FAM3A-induced increase in cytosolic free Ca2+ levels and attenuated FAM3A-mediated PI3K/Akt activation. Moreover, FAM3A-induced Akt activation was completely abolished by the inhibition of calmodulin (CaM).(M1008-10)