Endothelin B Receptor Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112181-100µl
$279.00Price

Fig1: Western blot analysis of Endothelin B Receptor on different cells lysates using anti-Endothelin B Receptor antibody at 1/500 dilution.

Positive control:

Lane 1: Zebrafish

Lane 2: Raji

Line 3: JAR

 

 

Bon Opus Cat. #BA112181
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Zebrafish
  • Immunogen

    Recombinant protein
  • Application Summary

    WB,IP
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Endothelin B receptor, Endothelin receptor non-selective type
  • Background

    Endothelin receptor B (ETBR), also known as EDNRB, ETB, ETRB, HSCR and HSCR2, is a member of the guanine-binding, regulatory protein-coupled receptor family. Three isoforms of ETBR exist called isoform 1, isoform 2 and δ 3. ETBR is involved in the regulation of sodium excretion and glomular filtration rate (GFR). ETBR plays a role in the normal development of the neural crestderived cell lineages, epidermal melanocytes and enteric neurons. ETBR is expressed in lung, kidney, placenta, skeletal muscle and stem villi vessels. Both of the ET receptors, ETAR and ETBR, are activated by ET1, which results in inhibition of active lens sodium-potassium transport. Activation of the ET receptors also causes an increase in cytoplasmic calcium concentration in cultured lens epithelial cells. ETBR deficiency causes early onset dysfunction of the kidney, characterized by reduced sodium excretion, decreased GFR and slightly elevated blood pressure. Mutations in the gene encoding ETBR produce congenital aganglionic megacolon and pigment abnormalities. The multigenic disorder, Hirschsprung’s disease type 2, is also due to a mutation in the ETBR gene.(ET1703-79)

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