EGR2 Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of EGR2 on MCF-7 and SH-SY-5Y cell lysates using anti-EGR2 at 1/500 dilution.
Fig2: Flow cytometric analysis of SH-SY-5Y cells with EGR2 antibody at 1/50 dilution (Fuchsia) compared with an unlabelled control (cells without incubation with primary antibody; Yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
ImmunogenRecombinant protein within human EGR2 aa 1-200
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesE3 SUMO-protein ligase EGR2, AT591, E3 SUMO-protein transferase ERG2, Early growth response protein 2, Zinc finger protein Krox-20
BackgroundThe protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene.(ET7108-57)