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E-Cadherin Mouse monoclonal Antibody IgG1

SKU: BA110242-100µl

Fig1: Western blot analysis of E-cadherin on  different cell lysates using anti- E-cadherin  antibody at 1/1000 dilution.

Positive control: 

  Lane 1: A431 

  Lane 2: SW480 

  Lane 3: MCF-7 

  Lane 4: Hela

Fig2: ICC staining E-Cadherin in A431 cells (red).  Cells were fixed in paraformaldehyde, permeabilised  with 0.25% Triton X100/PBS.

Fig3: Immunohistochemical analysis of  paraffin-embedded human liver carcinoma tissue  using E-Cadherin antibody. Counter stained with  hematoxylin.

Bon Opus Cat. #BA110242
  • Host Species; Species Reactivity

    Mouse; Human, Mouse
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, ICC, IHC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Cadherin-1,ARC-1,Epithelial cadherin
  • Background

    E-cadherin (epithelial) is the most well-studied member of the cadherin family. It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin. The intracellular domain contains a highly-phosphorylated region vital to beta-catenin binding and, therefore, to E-cadherin function. Loss of E-cadherin function or expression has been implicated in cancer progression and metastasis. E-cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. This in turn may allow cancer cells to cross the basement membrane and invade surrounding tissues. E-cadherin is also used by pathologists to diagnose different kinds of breast cancer.(EM0502)