DNA Ligase I Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of DNA Ligase I on different cell lysates using anti-DNA Ligase I antibody at 1/500 dilution.
Lane 1: Daudi
Lane 2: A431
Lane 3: MCF-7
Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-DNA Ligase I antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-DNA Ligase I antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Rat
ImmunogenRecombinant protein within C terminal human DNA Ligase.
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesDNA ligase 1, DNA ligase I, Polydeoxyribonucleotide synthase [ATP] 1
BackgroundThis gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.(ET7107-14)