DDAH2 Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of DDAH2 on different tissue lysates using anti-DDAH2 antibody at 1/2,000 dilution.
Lane 1: Rat heart
Lane 2: Mouse heart
Lane 3: Mouse lung
Lane 4: Human lung
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
ImmunogenSynthetic Peptide within Human DDAH2 aa 1-100
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesN(G),N(G)-dimethylarginine dimethylaminohydrolase 2, DDAHII, Dimethylargininase-2, Protein G6a, S-phase protein
BackgroundDDAH, a dimethylarginine dimethylaminohydrolase, hydrolyzes dimethyl arginine (ADMA) and monomethyl arginine (MMA), both inhibitors of nitric oxide synthases, and may be involved in in-vivo modulation of nitric oxide production. Impairment of DDAH causes ADMA accumulation and a reduction in cGMP generation. DDAH II, the predominant DDAH isoform in endothelial cells, facilitates the induction of nitric oxide synthesis by all-trans-Retinoic acid (atRA). DDAH proteins are highly expressed in colon, kidney, stomach and liver tissues.(ET7107-41)