Cytokeratin-7 Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of Cytokeratin-7 on different cell lysates using anti- Cytokeratin-7 antibody at 1/1000 dilution.
Lane 1: MCF-7
Lane 2: A549
Lane 3: Hela
Lane 4: HepG2
Lane 5: SKBR3 Lane 6: SKOV3
Lane 7: SW1990
Fig2: Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using anti-Cytokeratin-7 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-Cytokeratin-7 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityMouse; Human
Application SummaryWB, IHC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesKeRatin, type II cytoskeletal 7,KeRatin-7,Sarcolectin,Type-II keRatin Kb7
BackgroundKeratin-7 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. Keratin-7 is found in simple glandular epithelia, and in transitional epithelium. Epithelial cells of the lung and breast both contain keratin-7, but some other glandular epithelia, such as those of the colon and prostate, do not. Because the keratin-7 antigen is found in both healthy and neoplastic cells, antibodies to CK7 can be used in immunohistochemistry to distinguish ovarian and transitional cell carcinomas from colonic and prostate cancers, respectively.(EM0702)