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Cystatin C Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111974-100µl
$279.00Price

Fig1: Western blot analysis of Cystatin C on different lysates using anti-Cystatin C antibody at 1/1,000 dilution.

Positive control:   

Lane 1: Hela      

Lane 2: Mouse spleen

Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Cystatin C antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Cystatin C antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA111974
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Cystatin-C, Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin
  • Background

    Cystatin C is a cysteine (thiol) protease inhibitor that belongs to the type II cystatin gene superfamily and is the most abundant extracellular inhibitor of cysteine proteases. Cystatin C is a constitutively secreted, amyloidogenic protein, which forms a two-fold symmetric dimer and modulates both cysteine protease activity and the expression of class II MHC molecules. Expression of cystatin C is an indicator of kidney function and glomerular filtration rate. Mutations in the cystatin C gene can lead to protein aggregates, which are implicated in hereditary amyloid angiopathy (HCCAA) and cerebral hemorrhage. Although both wild-type and mutant cystatin C are capable of forming concentration dependent inactive dimers, mutant cystatin C dimerizes at lower concentrations and is more susceptible to serine proteases, which may facilitate aggregation. In neuronal cells, oxidative stress stimulates expression of cystatin C, which may positively regulate apoptosis.(ET1701-72)