CSF3 Mouse monoclonal Antibody IgG2a

SKU: BA112735-100µl

Fig1: Western blot analysis of G-CSF on human G-CSF recombinant protein using anti- G-CSF antibody at 1/1,000 dilution.

Fig2: Western blot analysis of G-CSF on HEK293 (1) and G-CSF-hIgGFc transfected HEK293 (2) cell lysate using anti-G-CSF antibody at 1/1,000

Fig3: Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissue using anti- G-CSF antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA112735
  • Host Species; Species Reactivity

    Mouse; Human
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, ICC, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1
  • Background

    Granulocyte-colony stimulating factor, G-CSF, is a pleiotropic cytokine that influences differentiation, proliferation and activation of the neutrophilic granulocyte lineage. The murine G-CSF cDNA encodes a 208 amino acid precursor containing a 30 amino acid signal peptide that is proteolytically cleaved to form a 178 amino acid residue mature protein. Two G-CSF cDNAs, which are identical except for a three amino acid deletion in the N-terminus of one form of the protein, have been isolated from human cells. Murine and human G-CSF share 73% sequence identity at the amino acid level. G-CSF signals through the G-CSF receptor, G-CSFR, a heavily glycosylated 812 amino acid polypeptide with a single transmembrane domain. Stimulation of the G-CSFR results in the activation of the Ras/MAPK pathway and phosphorylation of the adaptor protein Shc. Studies indicate that the kinases Lyn and Syk and the transcription factor Stat3 are activated in response to G-CSF stimulation.(EM1706-38)

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