CREB Recombinant Rabbit monoclonal Antibody IgG

CREB Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111290-100µl

Fig1: Western blot analysis of CREB on different cell lysates using anti-CREB antibody at 1/1,000 dilution.

Positive control: 

  Lane 1: Hela 

  Lane 2: HepG2 

  Lane 3: Jurkat 

  Lane 4: NIH/3T3

Fig2: ICC staining CREB in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CREB antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA111290
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat, Zebrafish
  • Immunogen

    Recombinant protein
  • Application Summary

  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Cyclic AMP-responsive element-binding protein 1
  • Background

    Eukaryotic gene transcription is regulated by sequence-specific transcription factors that bind modular cis-acting promoter and enhancer elements. The ATF/CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The ATF/CREB family includes CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. This family of proteins contains highly divergent N-terminal domains, but shares a C-terminal leucine zipper for dimerization and DNA binding. Although CREB can bind to DNA in an unphosphorylated state, it cannot activate transcription. Phosphorylation of CREB on Ser 133 by protein kinase A facilitates its interaction with the CREB-binding protein (CBP) and activates the basal transcription complex. CREB functions in neoglucogenesis through interactions with the nuclear coactivator PGC-1. CREB may play a role in the pathogenesis of type II diabetes and dilated cardiomyopathy.(ET1601-15)

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