Complement C3 (β- chain） Mouse monoclonal Antibody IgG2b
Fig1: Western blot analysis on human plasma lysates using anti-C3(β-chain) Mouse mAb (Cat. # M0809-14).
Host Species; Species ReactivityMouse; Human
Application SummaryWB, ICC, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesComplement C3,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
BackgroundHuman Complement C3 (C3) is synthesized as a single-chain pro-molecule (185 kDa) that tsuffers several posttranslational modifications. Before being a mature protein, C3 is split into beta-chain (70 kDa) and alpha chain (115 kDa) and forms a rare internal thioester bond. C3 plays a central role in the activation of the complement system. It’s processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.(M0809-14)