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CLOCK Rabbit polyclonal Antibody IgG

SKU: BA110184-100µl
$279.00Price

Fig1: Western blot analysis on different lysates using anti-CLOCK rabbit polyclonal antibody. Positive control: 

Lane 1: PC-12       

Lane 2: NIH/3T3 

Lane 3: Hela        

Lane 4: MCF-7 

Lane 5: Mouse brain  

Lane 6: Mouse kidney

Fig2: Immunocytochemical staining of PC-3M cells using anti-CLOCK rabbit polyclonal antibody.

Fig3: Immunocytochemical staining of SW480 cells using anti-CLOCK rabbit polyclonal antibody.

Bon Opus Cat. #BA110184
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Peptide
  • Application Summary

    WB, ICC, IHC, FC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Circadian locomoter output cycles protein kaput,Class E basic helix-loop-helix protein 8
  • Background

    Biological timepieces called circadian clocks are responsible for the regulation of hormonal rhythms, sleep cycles and other behaviors. The superchiasmatic nucleus (SCN), which is located in the brain, was the first mammalian circadian clock to be discovered. Clock, a member of the basic-helix-loop-helix-PAS (bHLH-PAS) family of transcription factors, has also been identified as having circadian function. Mutations within the Clock gene have been shown to increase the length of the endogenous period and to cause a loss of rhythmicity of circadian oscillations. Clock contains a DNA-binding domain, a protein dimerization domain and a glutamine-rich C-terminal region, which indicates transactivation capabilities. It has been speculated that Clock may regulate circadian rhythmicity in combination with other proteins such as Per. Per is also a PAS-domain containing protein that exhibits circadian function. Highest expression of Clock is seen in the hypothalamus and the eye.(R1511-2)