Clathrin heavy chain Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of Clathrin heavy chain on Hela (1) and PC-12 (2) cell lysate using anti-Clathrin heavy chain antibody at 1/1,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human adrenal gland tissue using anti-Clathrin heavy chain antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Clathrin heavy chain antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, IHC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesClathrin heavy chain 2, Clathrin heavy chain on chromosome 22
BackgroundClathrin is a major cytosolic coat protein in pits and vesicles originating from the plasma membrane and the trans-Golgi network. In receptor-mediated endocytosis, receptor proteins are englufed by clathrin-coated vesicles. Clathrin is composed of three heavy chains and three light chains which associate non-covalently to form a triskelion structure. Clathrin heavy chain (HC) is composed of a terminal globular domain, a distal segment and a proximal segment containing a light chain binding site. The proximal segment of the Clathrin HC protein is essential for interactions between clathrin heavy chains and light chains which result in the formation of the triskelion structure.(ET1704-50)