CHRNA4 Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of EZR on human EZR recombinant protein using anti-EZR antibody at 1/1,000 dilution.
Fig2: Western blot analysis of EZR on HEK293 (1) and EZR-hIgGFc transfected HEK293 (2) cell lysate using anti-EZR antibody at 1/1,000 dilution.
Fig3: Western blot analysis of EZR on different cell lysate using anti-EZR antibody at 1/1,000 dilution.
Positive control: Line1: MCF-7 Line2: Hela Line3: A431 Line4: Hek293 Line5: SK-N-SH Line6: Jurkat Line7: HepG2 Line8: NIH/3T3 Line9: Cos7
Host Species; Species ReactivityMouse; Human
Application SummaryWB, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesFibrocystin, Polycystic kidney and hepatic disease 1 protein, Polyductin, Tigmin
BackgroundMembers of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChRα4, also known as EBN, BFNC, EBN1, NACHR, NACRA4, NACHRA4 or CHRNA4, is a 627 amino acid multi-pass membrane protein associated with nocturnal frontal lobe epilepsy type 1 (ENFL1), an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.(EM1706-80)