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CENPC Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112587-100µl

Fig1: Western blot analysis of CENPC on K562 cell lysate using anti-CENPC antibody at 1/1,000 dilution.

Fig2: ICC staining CENPC in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Fig3: Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti-CENPC antibody. Counter stained with hematoxylin. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6) for 20 mins.

Bon Opus Cat. #BA112587
  • Host Species; Species Reactivity

    Rabbit; Human
  • Immunogen

    Recombinant protein within human CENPC aa 400-600.
  • Application Summary

  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Centromere protein C, Centromere autoantigen C, Centromere protein C 1, Interphase centromere complex protein 7
  • Background

    A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The evolutionarily conserved Centromere Protein-C, CENP-C, is a kinetochore assembly protein. CENP-C is located on the fibers of the kinetochore and constitutes a kinetochore organizing center that tightly associates with DNA. CENP-C is necessary for the formation of a functional centromere, which indicates that CENP-C is important for mitotic progression. In addition, CENP-C is lost from centromeres during herpes simplex virus 1 infection, causing substantial structural changes in the kinetochore, which suggests that the structure of CENP-C is regulated during the cell cycle.(ET7108-24)