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©2019 by Bon Opus Biosciences, LLC.

CD34 Rabbit polyclonal Antibody IgG

SKU: BA110152-100µl
$279.00Price

Fig1: Western blot analysis of CD34 on different cell lysates using anti-CD34antibody at 1/1000 dilution.

Positive control:    

Lane 1: Human brain   

Lane 2: Mouse brain  

Lane 3: Mouse testis   

Lane 4: Mouse thymus  

Lane 5: Mouse spleen  

Lane 6:Jurkat  

Lane 7: TF-1          

 Lane 8: F9

Fig2: ICC staining CD34 in hES cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD34 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA110152
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Peptide
  • Application Summary

    WB, ICC, IHC, FC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Hematopoietic progenitor cell antigen CD34,CD_antigen: CD34
  • Background

    CD34 is a heavily glycosylated type I transmembrane molecule, that can be phoshorylated by a variety of kinases including Protein kinase C and Tyrosine kinases. CD34 antigen is expressed on small vessel endothelial cells and tumors of epithelial origin. CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. So CD34 is considered to be ideal marker for identifying and quantifying hematopoietic progenitor stem cells. With interaction with CrkL, CD34 becomes a substrate for PKC and CD34 surface expression is associated with activation of PKC.(ER0802)