CD32 Recombinant Rabbit monoclonal Antibody IgG

CD32 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112145-100µl
$279.00Price

Fig1: Western blot analysis of CD32 on human lung cells lysates using anti-CD32 antibody at 1/500 dilution.

Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD32 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-CD32 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA112145
Size
  • Host Species; Species Reactivity

    Rabbit; Human
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Low affinity immunoglobulin gamma Fc region receptor II-a, CDw32, Fc-gamma RII-a, CD32
  • Background

    CD32 (also designated Fc gamma RII) is a low affinity receptor for the Fc fragment of aggregated IgG (1,2). CD32 is responsible for the clearance of immunocomplexes by macrophages and also plays an important role in the regulation of antibody production by B cells (1-4). IgG can noncooperatively bind either one or two highly glycosylated CD32 molecules, and this binding delivers a negative signal for B cells (1,2,5). CD32 exists as several isoforms that are produced by alternative splicing of three distinct genes, A, B, and C (2,6). These isoforms are designated FcgRIIA, FcgRIIB1, FcgRIIB3, and FcgRIIC (1,2,6). All isoforms are present on monocytes, placental trophoblasts and endothelial cells (1,6). In addition, the FcgRIIB forms are present on B lymphocytes, and the FcgRIIA and FcgRIIC forms are found on neutrophils (1,6).(ET1703-43)

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