CD271 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on D3 (A) and PC12 (B) using anti-CD271 polyclonal antibody.
Host Species; Species ReactivityRabbit; Mouse, Rat
Application SummaryWB, ICC, IHC, FC
Purification; FormulationImmunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesTumor necrosis factor receptor superfamily member 16,Low affinity neurotrophin receptor p75NTR,Low-affinity nerve growth factor receptor,CD_antigen: CD271
BackgroundNGFR p75 or CD271 is a 75kD transmembrane glycoprotein consisting of an extracellular domain which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain, and a cytoplasmic domain. NGFR p75 displays paradoxical functions when acting alone or with other receptor proteins. Working in concert with Trk receptors, it recognizes neurotrophins and transmits trophic signals into the cell. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system.(1003-9)