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CCL3 Rabbit polyclonal Antibody IgG

SKU: BA110129-100µl
$279.00Price

Fig1: Immunocytochemical staining of Hela cells using anti-CCL3 rabbit polyclonal antibody.

Fig2:  Immunocytochemical staining of PANC-1 cells using anti-CCL3 rabbit polyclonal antibody.

Fig3:  Immunocytochemical staining of A549 cells using anti-CCL3 rabbit polyclonal antibody.

Bon Opus Cat. #BA110129
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse
  • Immunogen

    Peptide
  • Application Summary

    ICC, IHC, FC, ELISA
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    C-C motif chemokine 3,Macrophage inflammatory protein 1-alpha,Small-inducible cytokine A3
  • Background

    Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1α, MIP-1β, MIP-2, MIP-3α, MIP-3β, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1β is more selective than MIP-1α, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1α is a more potent lymphocyte chemoattractant than MIP-1β and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1α has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1β and RANTES.(R1510-10)