CCL3 Rabbit polyclonal Antibody IgG
Fig1: Immunocytochemical staining of Hela cells using anti-CCL3 rabbit polyclonal antibody.
Fig2: Immunocytochemical staining of PANC-1 cells using anti-CCL3 rabbit polyclonal antibody.
Fig3: Immunocytochemical staining of A549 cells using anti-CCL3 rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human, Mouse
Application SummaryICC, IHC, FC, ELISA
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesC-C motif chemokine 3,Macrophage inflammatory protein 1-alpha,Small-inducible cytokine A3
BackgroundChemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1α, MIP-1β, MIP-2, MIP-3α, MIP-3β, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. Research has shown that MIP-1β is more selective than MIP-1α, primarily attracting CD4+ T lymphocytes, with a preference for T cells of the naive phenotype. MIP-1α is a more potent lymphocyte chemoattractant than MIP-1β and exhibits a broader range of chemoattractant specificities. It has been suggested that CD8+ T lymphocytes are involved in the control of HIV infection in vivo by the release of HIV-suppressive factors (HIV-SF). MIP-1α has been identified as one of the major HIV-SFs produced by CD8+ T cells, along with MIP-1β and RANTES.(R1510-10)