CCDC51 Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of CCDC51 on recombinant protein using anti-CCDC51 antibody at 1/1,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CCDC51 antibody. Counter stained with hematoxylin
Fig3: Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-CCDC51 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityMouse; Human
Application SummaryWB, IHC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesCoiled-coil domain-containing protein 51
BackgroundThe coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC51 (coiled-coil domain containing 51) is a 411 amino acid multi-pass membrane protein that exists as two alternatively spliced isoforms. The gene encoding CCDC51 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.(M1004-7)