Cathepsin B Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on cell lysates using anti- Cathepsin B rabbit polyclonal antibodies.
Fig2: ICC staining Cathepsin B in Hela cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS and counterstained with DAPI in order to highlight the nucleus (blue).
Host Species; Species ReactivityRabbit; Human
ImmunogenSynthetic Peptide (KLH-coupled) within human Cathepsin B C-terminal.
Application SummaryWB, ICC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesCathepsin B,APP secretase,Cathepsin B1
BackgroundCathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. In humans, it is coded by the CTSB gene. A wide array of diseases results in elevated levels of cathepsin B, which causes numerous pathological processes including cell death, inflammation, and production of toxic peptides. Focusing on neurological diseases, cathepsin B gene knockout studies in an epileptic rodent model have shown cathepsin B causes a significant amount of the apoptotic cell death that occurs as a result of inducing epilepsy. Mutations in the CTSB gene have been linked to tropical pancreatitis, a form of chronic pancreatitis.(R1407-1)