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Cathepsin B Rabbit polyclonal Antibody IgG

SKU: BA110123-100µl
$279.00Price

Fig1: Western blot analysis on cell lysates using anti- Cathepsin B rabbit polyclonal antibodies.

Fig2: ICC staining Cathepsin B in Hela cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS and counterstained with DAPI in order to highlight the nucleus (blue).

 

Bon Opus Cat. #BA110123
Size
  • Host Species; Species Reactivity

    Rabbit; Human
  • Immunogen

    Synthetic Peptide (KLH-coupled) within human Cathepsin B C-terminal.
  • Application Summary

    WB, ICC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Cathepsin B,APP secretase,Cathepsin B1
  • Background

    Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. In humans, it is coded by the CTSB gene. A wide array of diseases results in elevated levels of cathepsin B, which causes numerous pathological processes including cell death, inflammation, and production of toxic peptides. Focusing on neurological diseases, cathepsin B gene knockout studies in an epileptic rodent model have shown cathepsin B causes a significant amount of the apoptotic cell death that occurs as a result of inducing epilepsy. Mutations in the CTSB gene have been linked to tropical pancreatitis, a form of chronic pancreatitis.(R1407-1)