Caspase-9 Rabbit polyclonal Antibody IgG

SKU: BA110119-100µl
$279.00Price

Fig1: Western blot analysis on Hela cell lysates using anti-Caspase-9 rabbit polyclonal antibodies.

Fig2: Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using anti-Caspase-9 rabbit polyclonal antibody.

 

Bon Opus Cat. #BA110119
Size
  • Host Species; Species Reactivity

    Rabbit; Human
  • Immunogen

    Peptide
  • Application Summary

    WB, IHC
  • Purification; Formulation

    Immunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Caspase-9,Apoptotic protease Mch-6,Apoptotic protease-activating factor 3,ICE-like apoptotic protease 6
  • Background

    Caspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family. It is known to be involved in the activation cascade of caspases responsible for apoptosis execution. Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf 1. Apaf-1 mediated activation of caspase-9 involves instrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response. Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis.(R1308-12)

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