Caspase-9 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on Hela cell lysates using anti-Caspase-9 rabbit polyclonal antibodies.
Fig2: Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using anti-Caspase-9 rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human
Application SummaryWB, IHC
Purification; FormulationImmunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesCaspase-9,Apoptotic protease Mch-6,Apoptotic protease-activating factor 3,ICE-like apoptotic protease 6
BackgroundCaspase-9 (ICE-LAP6, Mch6) is an important member of the cysteine aspartic acid protease (caspase) family. It is known to be involved in the activation cascade of caspases responsible for apoptosis execution. Upon apoptotic stimulation, cytochrome c released from mitochondria associates with the 47 kDa procaspase-9/Apaf 1. Apaf-1 mediated activation of caspase-9 involves instrinsic proteolytic processing resulting in cleavage at Asp315 and producing a p35 subunit. Another cleavage occurs at Asp330 producing a p37 subunit that can serve to amplify the apoptotic response. Cleaved caspase-9 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, which leads to apoptosis.(R1308-12)