Caspase-1 Mouse monoclonal Antibody IgG1
Fig1: Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti- Caspase-1 Mouse mAb.
Fig2: Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti- Caspase-1 Mouse mAb.
Fig3: Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using anti- Caspase-1 Mouse mAb.
Host Species; Species ReactivityMouse; Human, Mouse, Rat
Application SummaryWB, ICC, IHC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesCaspase-1,Interleukin-1 beta convertase,Interleukin-1 beta-converting enzyme,p45
BackgroundCaspase 1 is produced as a zymogen that is cleaved into 20 kDa (p20) and 10 kDa (p10) subunits that become part of the active enzyme. Active caspase 1 contains two heterodimers of p20 and p10. It interacts with another CARD domain containing protein called PYCARD (or ASC) and is involved in inflammasome formation and activation of inflammatory processes. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages. Studies of a similar protein in mouse suggest a role in the pathogenesis of Huntington's disease. Alternative splicing of the gene results in five transcript variants encoding distinct isoforms. Recent studies implicated caspase 1 in promoting CD4 T-cell death and inflammation by HIV, two signature events that fuel HIV disease progression to AIDS.(M1505-2)