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©2019 by Bon Opus Biosciences, LLC.

CAMK2G Mouse monoclonal Antibody IgG1

SKU: BA112713-100µl
$279.00Price

Fig1: Western blot analysis of CaMKII gamma on  human CaMKII gamma  recombinant protein using anti- CaMKII gamma antibody at 1/1,000 dilution.

Fig2: Western blot analysis of CaMKII gamma on HEK293 (1) and CaMKII gamma -hIgGFc transfected HEK293 (2) cell lysate using anti- CaMKII gamma antibody at 1/1,000 dilution.

Fig3: Western blot analysis of CaMKII gamma on different cell lysate using anti- CaMKII gamma antibody at 1/1,000 dilution.

Positive control: Line1: PC-12          Line2: Jurkat Line3: T47D           Line4:HepG2

Bon Opus Cat. #BA112713
Size
  • Host Species; Species Reactivity

    Mouse; Human, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    GTP-binding nuclear protein Ran, Androgen receptor-associated protein 24, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein
  • Background

    The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory Threonine residue at position 177.(EM1706-16)