Calnexin Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis of Calnexin on mouse lung tissue (1) and Daudi cell (2) lysate using anti-Calnexin antibody at 1/500 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-Calnexin antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-Calnexin antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Mouse
ImmunogenSynthetic Peptide within C-terminal residues of rat Calnexin.
Purification; FormulationPeptide affinity purified.; 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesCalnexin, IP90, Major histocompatibility complex class I antigen-binding protein p88, p90
BackgroundCalnexin and Calregulin (also called calreticulin) are calcium-binding proteins that are localized to the endoplasmic reticulum, Calnexin to the membrane and Calregulin to the lumen. Calnexin is a type I membrane protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may play a role in assisting with protein assembly and in retaining unassembled protein subunits in the endoplasmic reticulum. Calregulin has both low- and high-affinity calcium-binding sites. Neither Calnexin nor Calregulin contains the calcium-binding “E-F hand” motif found in calmodulins. Calnexin and Calregulin are important for the maturation of glycoproteins in the endoplasmic reticulum and appear to bind many of the same proteins.(ER1803-42)