BTRC Mouse monoclonal Antibody IgG1
Bon Opus Cat. #BA112776
Host Species; Species ReactivityMouse; Human
Application SummaryWB, IHC, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesNucleoside diphosphate kinase B, C-myc purine-binding transcription factor PUF, Histidine protein kinase NDKB, nm23-H2
Backgroundb-tranducin repeats containing protein (b-TrCP), also designated E3RSIkB or FWD1, and HOS (homologous to Slimb) are F-box proteins that function as substrate recognition subunits of ubiquitin ligases. HOS and b-TrCP differ in their amino-terminal regions, but exhibit high homology within the F-box and WD40 repeat-containing regions. b-TrCP mediates ubiquitin/proteasome-dependent degradation of CD4 and ubiquitination of various proteins including IkB and b-catenin. HOS has also been shown to regulate the degradation of IkB and b-catenin in a similar manner.(EM1706-79)