BRCA2 Mouse monoclonal Antibody IgG1

SKU: BA110101-100µl
$279.00Price

Fig1: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti- BRCA2 mouse mAb.

Fig2: ICC staining BRCA2 in MCF-7 cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS and counterstained with DAPI in order to highlight the nucleus (blue).

 

Bon Opus Cat. #BA110101
Size
  • Host Species; Species Reactivity

    Mouse; Human
  • Immunogen

    Recombinant protein
  • Application Summary

    ICC, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Breast cancer type 2 susceptibility protein,Fanconi anemia group D1 protein
  • Background

    BRCA2 (breast cancer type 2 susceptibility protein) belongs to the tumor suppressor gene family, and orthologs have been identified in most mammals for which complete genome data are available. The protein encoded by this gene is involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double strand breaks. Certain variations of the BRCA2 gene increase risks for breast cancer as part of a hereditary breast-ovarian cancer syndrome. Researchers have identified hundreds of mutations in the BRCA2 gene, many of which cause an increased risk of cancer. BRCA2 mutations are usually insertions or deletions of a small number of DNA base pairs in the gene.(M1310-4)

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