BMPR1A Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on 293 cell lysates using anti-BMPR1A rabbit polyclonal antibody.
Fig2: Immunocytochemical staining of Hela cells using anti-BMPR1A rabbit polyclonal antibody.
Fig3: Immunocytochemical staining of HepG2 cells using anti-BMPR1A rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, ICC, IHC, FC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesBone morphogenetic protein receptor type-1A,Activin receptor-like kinase 3,Serine/threonine-protein kinase receptor R5,CD_antigen: CD292
BackgroundMembers of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Two type I receptors have been characterized, BMPR-IA (also designated SKR5, ALK-3, and BRK-1) and BMPR-IB (also designated ALK-6 and SKR 6), that bind to bone morphogenetic proteins (BMP)-2, BMP-4, and osteogenic protein (OP)-1 (also designated BMP-7). BMPR-IA and BMPR-IB are both expressed in human glioma cell lines. The type II receptor, BMPR-II, efficiently binds to OP-1 and BMP-2 and weakly binds BMP-4, and it is widely expressed in different tissues, including brain. The BMP receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morphogenesis in a dose dependent fashion.(R1510-1)