BMP4 Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of BMP4 on human BMP4 recombinant protein using anti-BMP4 antibody at 1/1,000 dilution.
Fig2: Western blot analysis of BMP4 on HEK293 (1) and BMP4-hIgGFc transfected HEK293 (2) cell lysate using anti-BMP4 antibody at 1/1,000 dilution.
Fig3: Western blot analysis of BMP4 on A549 (1), HepG2 (2), and C6 (3) cell lysate using anti-BMP4 antibody at 1/1,000 dilution.
Host Species; Species ReactivityMouse; Human, Rat
Application SummaryWB, ICC, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesUV excision repair protein RAD23 homolog A
BackgroundTumor growth factor, or TGFβ, is the prototypic member of a family of secreted proteins that regulate cellular proliferation and differentiation. Related proteins include the activins and the bone morphogenic proteins or BMPs. Like TGFβ, the BMPs signal through a heteromeric receptor complex (TGFβ R) composed of type I (TGFβ RI) and type II (TGFβ RII) receptors. Both the type I and the type II receptors contain an intrinsic serine/threonine kinase activity. Although signaling downstream of the TGF β R is poorly understood, several proteins have been implicated. Six TGFβ/BMP effector proteins, designated Smad1-6, may function as tumor suppressors. Smad proteins have been suggested to be transcription factors, acting similarly to the Stat family which associates directly with activated receptors and then translocates to the nucleus. Evidence supporting this assertion is drawn from the observation that Smad3 physically associates with the TGFβ R complex and that Smad1 is translocated to the nucleus 30-60 minutes after the addition of BMP-4.(EM1706-23)