Beta-Catenin Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111310-100µl
$279.00Price

Fig1: Western blot analysis of Beta-Catenin on different cell lysates using anti- Beta-Catenin antibody at 1/1,000 dilution.

Positive control:

Lane 1: SW480

Lane 2: HT29

Lane 3: A431

Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti- Beta-Catenin antibody. Counter stained with hematoxylin.  

 

Fig3: Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti- Beta-Catenin antibody. Counter stained with hematoxylin.  

 

Bon Opus Cat. #BA111310
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, ICC, IHC, IP
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Catenin beta-1, Beta-catenin
  • Background

    β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. Phosphorylation at Ser-552 by AMPK promotes stabilizion of the protein, enhancing TCF/LEF-mediated transcription. Phosphorylation on Tyr-654 decreases CDH1 binding and enhances TBP binding. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.(ET1601-5)

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