Beclin 1 Rabbit polyclonal Antibody IgG
Fig1: Immunohistochemical analysis of paraffin-embedded human liver carcinoma tissue using anti- Beclin 1 rabbit polyclonal antibody.
Fig2: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti- Beclin 1 rabbit polyclonal antibody.
Fig3: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti- Beclin 1 rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
ImmunogenSynthetic Peptide (KLH-coupled) within human Beclin 1 aa 380-450.
Application SummaryICC, IHC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesBeclin-1,Coiled-coil myosin-like BCL2-interacting protein,Protein GT197
BackgroundPlays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in antiviral host defense.(R1509-1)