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Beclin 1 Rabbit polyclonal Antibody IgG

SKU: BA110084-100µl
$279.00Price

Fig1: Immunohistochemical analysis of paraffin-embedded human liver carcinoma tissue using anti- Beclin 1 rabbit polyclonal antibody.

Fig2: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti- Beclin 1 rabbit polyclonal antibody.

Fig3: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti- Beclin 1 rabbit polyclonal antibody.

Bon Opus Cat. #BA110084
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Synthetic Peptide (KLH-coupled) within human Beclin 1 aa 380-450.
  • Application Summary

    ICC, IHC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Beclin-1,Coiled-coil myosin-like BCL2-interacting protein,Protein GT197
  • Background

    Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role in antiviral host defense.(R1509-1)