BCR Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of BCR on human BCR recombinant protein using anti-BCR antibody at 1/1,000 dilution.
Fig2: Western blot analysis of BCR on HEK293 (1) and BCR-hIgGFc transfected HEK293 (2) cell lysate using anti-BCR antibody at 1/1,000 dilution.
Fig3: Western blot analysis of BCR on different cell lysate using anti-BCR antibody at 1/1,000 dilution.
Positive control: Line1: Jurkat Line2: Hela Line3: Ramos
Host Species; Species ReactivityMouse; Human
Application SummaryWB, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
BackgroundThe Bcr gene, mapping on chromosome 22, was initially identified on the basis of its fusion with the c-Abl proto-oncogene on chromosome 9 resulting in the generation of the Philadelphia chromosome in 90-95% of patients with chronic myelogenous leukemia (CML). The Bcr gene encodes for the breakpoint cluster region (Bcr) protein. A consequence of this translocation is the generation of a Bcr/c-Abl mRNA encoding an activated c-Abl protein kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, Rac 1 p21. While it has been speculated that the Bcr protein may also stimulate Rac 2 p21 GTPase activity, it has no effect on Ras p21 or Rho p21 GTPases. It is of interest that the GAP domain of Bcr maps outside of the region that remains on chromosome 22 (Philadelphia chromosome) in CML.(EM1706-88)