Autoimmune regulator Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on 293 cell (A) transfected and (B) none transfected with AIRE gene using anti-AIRE polyclonal antibody.
Fig2: Immunohistochemistry- staining AIRE in mouse thymus by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.
Fig3: AIRE staining (red) in mouse embryonic stem cells (D3) by immunocytochemistry, nuclear staining with DAPI (blue) and SSEA-1 staining (green).
Host Species; Species ReactivityRabbit; Mouse
Purification; FormulationImmunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesAutoimmune regulator,Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog
BackgroundThe Autoimmune Regulator (AIRE) is a human transcription factor expressed at higher level in thymus, pancreas, adrenal cortex, and testis. It is expressed at lower level in the spleen, fetal liver and lymph nodes. It contains zinc finger motifs and isoform 1 is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described. In the thymus it causes transcription of a wide selection of organ-specific genes which create proteins that are usually only expressed in peripheral tissues, creating an "immunological self-shadow" in the thymus. Defects in AIRE are a cause of autoimmune poly-endocrinopathy candidiasis ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type I (APS-1).(0908-2)