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Autoimmune regulator (AIRE) Rabbit polyclonal Antibody IgG

SKU: BA110069-100µl
$279.00Price

Fig1: Western blot-AIRE antibody A: 293T cell lysate, transfected with human AIRE B: 293T cell lysate, untransfected

 

 

Bon Opus Cat. #BA110069
Size
  • Host Species; Species Reactivity

    Rabbit; Human
  • Immunogen

    Peptide
  • Application Summary

    WB, IHC, FC
  • Purification; Formulation

    Immunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Autoimmune regulator,Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
  • Background

    The Autoimmune Regulator (AIRE) is a human transcription factor expressed at higher level in thymus, pancreas, adrenal cortex, and testis. It is expressed at lower level in the spleen, fetal liver and lymph nodes. It contains zinc finger motifs and isoform 1 is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described. In the thymus it causes transcription of a wide selection of organ-specific genes which create proteins that are usually only expressed in peripheral tissues, creating an "immunological self-shadow" in the thymus. Defects in AIRE are a cause of autoimmune poly-endocrinopathy candidiasis ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type I (APS-1).(R1107-1)