Autoimmune regulator (AIRE) Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on mouse AIRE gene transfected 293 cell lysates using anti-AIRE rabbit polyclonal antibodies.
Host Species; Species ReactivityRabbit; Human, Mouse
ImmunogenThis antibody is produced by immunizing rabbits with full length Recombinant protein of mouse AIRE.
Purification; FormulationImmunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesAutoimmune regulator,Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
BackgroundThe Autoimmune Regulator (AIRE) is a human transcription factor expressed at higher level in thymus, pancreas, adrenal cortex, and testis. It is expressed at lower level in the spleen, fetal liver and lymph nodes. It contains zinc finger motifs and isoform 1 is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described. In the thymus it causes transcription of a wide selection of organ-specific genes which create proteins that are usually only expressed in peripheral tissues, creating an "immunological self-shadow" in the thymus. Defects in AIRE are a cause of autoimmune poly-endocrinopathy candidiasis ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type I (APS-1).(R1305-5)