ATRX Mouse monoclonal Antibody IgG1
Fig1: ICC staining ATRX in mouse embryonic cells D3 (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig2: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti- ATRX mouse monoclonal antibody.
Host Species; Species ReactivityMouse; Mouse
ImmunogenThis antibody is produced by immunizing mice with Recombinant protein of mouse ATRX.
Application SummaryICC, IHC
Purification; FormulationProG affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesTranscriptional regulator ATRX,ATP-dependent helicase ATRX,HP1 alpha-interacting protein,HP1-BP38 protein,Heterochromatin protein 2,X-linked nuclear protein
BackgroundTranscriptional regulator ATRX contains an ATPase / helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations of the ATRX gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes.(M1311-2)