ATF6 Mouse monoclonal Antibody IgG

SKU: BA111202-100µl
$279.00Price

Fig1: Western blot analysis of ATF6 on SiHa cell lysate using anti-ATF6 antibody at 1/1,000 dilution.

Fig2: Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-ATF6 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-ATF6 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA111202
Size
  • Host Species; Species Reactivity

    Mouse; Human, Mouse, Rat
  • Immunogen

    Recombinant protein within full length sequence of human ATF6.
  • Application Summary

    WB,IHC,FC
  • Purification; Formulation

    ProG purified.; 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Cyclic AMP-dependent transcription factor ATF-6 alpha, Activating transcription factor 6 alpha, Processed cyclic AMP-dependent transcription factor ATF-6 alpha
  • Background

    Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N9-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.(EM1701-94)

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