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APAF1 Rabbit polyclonal Antibody IgG

SKU: BA110057-100µl
$279.00Price

Fig1: Western blot analysis on cell lysates using anti-APAF1 rabbit polyclonal antibodies.

 

 

Bon Opus Cat. #BA110057
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse
  • Immunogen

    Peptide
  • Application Summary

    WB
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Apoptotic protease-activating factor 1
  • Background

    Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene. This gene encodes a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. This protein contains (from the N terminal) a caspase recruitment domain (CARD), an ATPase domain (NB-ARC), few short helical domains and then several copies of the WD40 repeat domain. Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. The precise mechanism for this reaction is still debated though work published by Guy Salvesen suggests that the apoptosome may induce caspase 9 dimerization and subsequent autocatalysis. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis.(R1312-20)