Angiopoietin 2 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA113151-100µl
$279.00Price

Fig1: Western blot analysis of Angiopoietin 2 on different cell lysate using anti-Angiopoietin 2 antibody at 1/1,000 dilution.

Positive control:

  Lane 1: TF-1 

  Lane 2:  Human liver tissue

  Lane 3: Human placenta tissue

 

Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Angiopoietin 2 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-Angiopoietin 2 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA113151
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Background

    Tie-1 and Tie-2 (also designated Tek) are novel cell surface receptor tyrosine kinases. The extracellular domain of Tie-1 has an unusual multidomain structure consisting of a cluster of three epidermal growth factor homology motifs localized between two immunoglobulin-like loops, which are followed by three fibronectin type III repeats next to the transmembrane region. Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2. Preliminary biochemical analyses of Ang-1 reveal a potential fibrinogen-like domain at the carboxy terminus and coiled-coil regions in the amino terminus. Ang-1 is an angiogenic factor that is thought to be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), has been identified as a naturally occurring antagonist of Ang-1 activation of Tie-2. In adult tissue, Ang-2 expression seems to be restricted to sites of vascular remodeling.(ET1705-6)

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