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alpha Internexin Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112400-100µl

Fig1: Western blot analysis of alpha Internexin on different lysates using anti-alpha Internexin antibody at 1/1,000 dilution.

Positive control:

 Lane 1: Mouse brain tissue

  Lane 2: A549


Fig2: ICC staining alpha Internexin in PC-12 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Fig3: Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-alpha Internexin antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA112400
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Alpha-internexin, 66 kDa neurofilament protein, Neurofilament 5
  • Background

    Alpha-internexin is a brain specific type IV intermediate filament protein. This axonal protein is found in most, if not all, neurons of the CNS. The head domain of alpha-internexin is essential for self-assembly into a filament network. Expression levels of alpha-internexin have been shown to be maximal during late embryogenesis and to decline into adulthood, suggesting that this protein plays a role in regulatory processes during the development of the brain. The alpha-internexin promoter has been shown to be activated by Brn-3a or Brn-3c transcription factor binding, while Brn-3b binding to the promoter results in alpha-internexin repression.(ET1706-23)