Alpha-1 acid glycoprotein Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis of Alpha-1 Acid Glycoprotein on human liver tissue lysates using anti-Alpha-1 acid glycoprotein antibody at 1/500 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Alpha-1 Acid Glycoprotein antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-Alpha-1 Acid Glycoprotein antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Purification; FormulationProtein affinity purified; 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesAlpha-1-acid glycoprotein 1, Orosomucoid-1
BackgroundAGP (α1-acid glycoprotein) is an acute phase plasma protein synthesized by the liver. It functions to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, it also mediates the extravasation of cells during infection and inflammation. Expression of AGP is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides. AGP has a high affinity, low capacity binding for basic drugs at physiological pH. In human plasma, AGP is found at levels of 0.5-1.4 mg/ml, though this is elevated during acute inflammation, and, as a result, levels of this protein can be used to diagnose inflammatory conditions. AGP-1 and AGP-2 contain five and six potential N-glycosylation sites, respectively. Abnormal expression of the APG-1 gene is linked to sarcoidosis and other immunogenetic diseases, while mutations in the APG-2 gene are associated with different types of carcinomas.(ER1802-27)