ALIX Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of ALIX on different cell lysates using anti-ALIX antibody at 1/1,000 dilution.
Lane 1: Hela Lane 2: PC-12 Lane 3: NIH-3T3
Fig2: Immunohistochemical analysis of paraffin-embedded rat stomach tissue using anti-ALIX antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-ALIX antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, IHC, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesProgrammed cell death 6-interacting protein, ALG-2-interacting protein 1, ALG-2-interacting protein X, Hp95
BackgroundALG-2-interacting protein (Alix), also designated programmed cell death 6-interacting protein (PDCD6-interacting protein), is a cytoplasmic protein. Alix interacts with apoptosis-associated proteins (ALG-2 and PDCD6) and with the endocytosis-regulator CIN85. Additionally, Alix interacts with the endosomal sorting complexes required for transport (ESCRT) proteins (Tsg101 and CHMP4) and can associate with HIV-1. The endophilins (SH3P4, SH3P8 and SH3P13), enzymes that change curvature of the membrane that are required for early and late steps of coated vesicle formation, also bind to Alix. Alix is involved in the concentration and sorting of cargo proteins of the multivesicular body for incorporation into vesicles.(ET1705-74)