ALIX Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112356-100µl

Fig1: Western blot analysis of ALIX on different cell lysates using anti-ALIX antibody at 1/1,000 dilution.

  Positive control:

  Lane 1: Hela  Lane 2: PC-12  Lane 3: NIH-3T3

Fig2: Immunohistochemical analysis of paraffin-embedded rat stomach tissue using anti-ALIX antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-ALIX antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA112356
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Programmed cell death 6-interacting protein, ALG-2-interacting protein 1, ALG-2-interacting protein X, Hp95
  • Background

    ALG-2-interacting protein (Alix), also designated programmed cell death 6-interacting protein (PDCD6-interacting protein), is a cytoplasmic protein. Alix interacts with apoptosis-associated proteins (ALG-2 and PDCD6) and with the endocytosis-regulator CIN85. Additionally, Alix interacts with the endosomal sorting complexes required for transport (ESCRT) proteins (Tsg101 and CHMP4) and can associate with HIV-1. The endophilins (SH3P4, SH3P8 and SH3P13), enzymes that change curvature of the membrane that are required for early and late steps of coated vesicle formation, also bind to Alix. Alix is involved in the concentration and sorting of cargo proteins of the multivesicular body for incorporation into vesicles.(ET1705-74)

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