ALDH4A1 Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of ALDH4A1 on SK-Br-3 (1) and HepG2 (2) cell lysate using anti-ALDH4A1 antibody at 1/1,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-ALDH4A1 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityMouse; Human, Rat
ImmunogenSynthetic Peptide of C terminal human ALDH4A1.
Purification; FormulationProG affinity purified.; 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, Aldehyde dehydrogenase family 4 member A1, L-glutamate gamma-semialdehyde dehydrogenase
BackgroundAldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH4A1 (aldehyde dehydrogenase 4 family member A1), also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), P5CDh, P5CDhL, P5CDhS or ALDH4, is a major enzyme involved in the proline degradation pathway. Localizing to the mitochondrial matrix, ALDH4A1 catalyzes the conversion of Delta-1-pyrroline-5-carboxylate (P5C) to glutamate. A mutation in the gene encoding ALDH4A1 results in HPII (hyperprolinemia type II), a disease characterized by an excess of P5C and proline that is associated with mental retardation and seizures.(EM1701-75)