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ALDH2 Mouse monoclonal Antibody IgG1

SKU: BA110027-100µl
$279.00Price

Fig1: Western blot analysis on HepG2 cell lysates using anti- ALDH2 mouse mAb.

Fig2: ICC staining ALDH2 in HepG2 cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Fig3: Immunohistochemical analysis of paraffin-embedded human gastric carcinoma tissue using anti- ALDH2 mouse mAb.

Bon Opus Cat. #BA110027
Size
  • Host Species; Species Reactivity

    Mouse; Human
  • Immunogen

    Peptide
  • Application Summary

    WB, ICC, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Aldehyde dehydrogenase, mitochondrial,ALDH class 2,ALDH-E2,ALDHI
  • Background

    Aldehyde dehydrogenase 2 family (mitochondrial), also known as ALDH2, is a human gene found on chromosome 12. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. The ALDH2 gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Most Europeans have two major isozymes, while approximately 50% of Northeast Asians have one normal copy of the ALDH2 gene and one mutant copy that encodes an inactive mitochondrial isoenzyme. A remarkably higher frequency of acute alcohol intoxication among Northeast Asians than among Europeans has been repeatedly shown to be related to the very much reduced activity of the mutant ALDH2-2 isoenzyme.(M1501-7)