ALDH2 Mouse monoclonal Antibody IgG1

ALDH2 Mouse monoclonal Antibody IgG1

SKU: BA110028-100µl
$279.00Price

Fig1: Western blot analysis on HepG2 cells lysates using anti-ALDH2 Mouse mAb.

Fig2:  Immunocytochemical staining of HepG2 cells using anti-ALDH2 Mouse mAb.

Fig3:  Immunocytochemical staining of PC-3M cells using anti-ALDH2 Mouse mAb.

Bon Opus Cat. #BA110028
Size
  • Host Species; Species Reactivity

    Mouse; Human, Mouse, Rat
  • Immunogen

    Peptide
  • Application Summary

    WB, ICC/IF, IHC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Aldehyde dehydrogenase, mitochondrial, ALDH class 2, ALDH-E2, ALDHI
  • Background

    Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde; lipid peroxidation; and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1A1, also designated retinal dehydrogenase 1 (RalDH1 or RALDH1); aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase cytosolic; ALDHII; ALDH-E1 or ALDH E1, is a retinal dehydrogenase that participates in the biosynthesis of retinoic acid (RA). The major liver isoform ALDH1 localizes to cytosolic space, while ALDH2 localizzes to the mitochondria. The ALDH1A2 (RALDH2, RALDH2-T) gene produces three different transcripts and also catalyzes the synthesis of RA from retinaldehyde. ALDH2 is present in most Caucasians, yet is absent in 50% of Asians. The absence of this enzyme has been linked to alcohol intolerance; and thusly, a reduced risk for alcoholism-related liver disease.(M1509-1)

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