5 Lipoxygenase Rabbit polyclonal Antibody IgG

5 Lipoxygenase Rabbit polyclonal Antibody IgG

SKU: BA110949-100µl

Fig1: Western blot analysis of 5-lipoxygenase on Hela (1) and Jurkat (2) lysates using anti-5-lipoxygenase antibody at 1/1,000 dilution.



Bon Opus Cat. #BA110949
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

  • Application Summary

  • Purification; Formulation

    Peptide affinity purified.; 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Arachidonate 5-lipoxygenase
  • Background

    5-lipoxygenase (5-LO) is expressed primarily in polymorphonuclear leukocytes, macrophages, and mast cells. 5-LO performs the first two catalytic reactions in the biosynthesis of leukotrienes, lipid metabolites that induce contractions of airway smooth muscle and increase vascular permeability during anaphylaxis. The cellular localization of 5-LO varies between cell types. In activated blood polymorphonuclear leukocytes 5-LO undergoes calcium dependent translocation from the cytosol to the nuclear envelope. In alveolar macrophages, the majority of 5-LO is localized in the nucleus and, upon activation of these cells, intranuclear 5-LO binds to the nuclear membrane. This intracellular shuttling of 5-LO is dependent on the association with various signaling molecules, phosphorylation and the presence of a distinct(R1512-14)

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